Dedicated to enhance the lives of cancer patients who are facing limited therapeutic options, BriaCell Therapeutics Corp. (OTCQB: BCTXF; TSX: BCT.V)’s mission has been to develop novel immunotherapies, as the most cutting edge technology to fight cancer. Immunotherapies have become the forefront of the cancer treatments because they use the body’s immune system to destroy the cancer cells, offering higher levels of safety and efficacy than chemotherapy, with less likeliness of recurrence.
Designed by our team of scientists and clinicians, BriaCell’s proprietary whole-cell based technology platform continues to show its impressive potential to establish a new model for treating cancer patients. Our lead product candidate, Bria-IMT™ (SV-BR-1-GM), is a genetically engineered whole-cell based product candidate derived from a human breast cancer cell line. Bria-IMT™ is used in combination with multiple immune-modulators to powerfully trigger the immune system to recognize and eliminate cancerous cells.
In a preliminary Phase I clinical study in metastatic (i.e., Stage IV) breast cancer patients who had failed multiple treatments, Bria-IMT™ treatment significantly reduced the tumor size, without serious side effects. Importantly, the tumor regression was observed in other sites including the lung and even the brain -a difficult site. Impressively, the median lifespan of the patients was substantially longer than that of the comparable trials.
At our laboratory facility in Berkeley, CA, we are planning to expand our pipeline of oncology immunotherapy candidates using our proprietary technology platform.
Using the clinical data from the patients from the clinical studies, we are working to identify the molecular fingerprint of the patients for which Bria-IMT™ would be highly effective, and are planning to develop diagnostic testing products to identify this group. By directing the drug to the top-responders, we expect this approach to increase the likelihood of clinical trial success of Bria-IMT™ -to bring hope to thousands of cancer patients with few-to-no treatment options.
The company is currently recruiting its Phase I/IIa trial to further test Bria-IMT™ safety and activity in metastatic breast cancer patients. BriaCell maintains global rights for Bria-IMT™.
II. Breast Cancer: Facts & Statistics
Filed with the United States Patent and Trademark Office (USPTO), the U.S. patent application number US 7,674,456 B2, Priority Date: June 14, 2004, includes the following:
On March 7, 2017, BriaCell filed an international patent application under the Patent Cooperation Treaty (PCT) to further expand its intellectual property portfolio underlying the Company’s current and anticipated pipeline of whole-cell cancer vaccines, including Bria-IMT™, and related companion diagnostic tests. The PCT application is designed to complement and extend on two patent applications filed by the Company with the United States Patent and Trademark Office (USPTO) in 2016, as well as the Company’s granted patent covering Bria-IMT™ (US 7,674,456 B2). The PCT patent application provides ways to generate additional whole-cell cancer vaccines and strategies for patient-specific selection of the most likely effective vaccine. BriaCell is developing its diagnostic, referred to as BriaDx™, in parallel to Bria-IMT™ in the ongoing Phase I/IIa clinical study in patients with advanced breast cancer.
Additional patent applications are expected to be filed in 2018.
Small Molecule Program
We recently disclosed the allowance by the US Patent and Trademark Office (USPTO) and also the European Patent Office (EPO) of two patent applications related to protein kinase C delta (PKCδ) inhibitor technology, titled “PKC Delta Inhibitors for use as Therapeutics”.
WILLIAM V. WILLIAMS, MD, FRCP, PRESIDENT & CEO
Dr. Williams is a seasoned biopharmaceutical executive with over 35 years of industry and academic expertise, including significant clinical management in multinational pharmaceutical companies. Dr. Williams served as VP of Exploratory Development at Incyte Corporation from 2005 – 2016. There he facilitated entry of over 20 compounds into the clinic, including ruxolitinib (Jakafi), baricitinib, and epacadostat. He was responsible for establishing proof-of-concept in several therapeutic areas, and has been involved in numerous new drug applications (NDAs) for therapeutics that achieved marketing authorization in multiple therapeutic areas including oncology. This includes Jakafi for myelofibrosis and polycythemia vera and baricitinib for rheumatoid arthritis.
GADI LEVIN, CA, MBA, CFO & CORPORATE SECRETARY
Mr. Gadi Levin has been appointed as BriaCell Therapeutics Corp.’s Chief Financial Officer in February 2016. Most recently, he acted as Chief Financial Officer of Labstyle Innovations Ltd, a biotechnology company focused on diabetes.
MARKUS LACHER, PH.D. SENIOR DIRECTOR, R&D
Dr. Lacher has joined BriaCell Therapeutics in July 2015. Previously, he served as a Senior Clinical Scientist, R&D at Cesca Therapeutics, Inc., a clinical-stage autologous cell therapy company where he played a lead role in the bone marrow transplantation program.
FARRAH DEAN, MSC, MBA, MANAGER, CORPORATE DEVELOPMENT
Farrah serves as Manager, Corporate Development at BriaCell Therapeutics Corp. Her experience includes working in investor relations at CytRx Corporation, and CCG Investor Relations. Farrah’s prior experience include Senior Associate Analyst in Equity Research at Oppenheimer & Co., Rodman & Renshaw, and ThinkEquity LLC.
BriaCell Therapeutics Corp. (BriaCell) is an immuno-oncology company which develops immunotherapy treatments for cancer. BriaCell is currently focused on the clinical development of Bria-IMT™ as a 2nd line treatment for patients with advance forms of breast cancer. In two Phase I clinical trials in Stage IV breast cancer patients who had failed prior treatments, the lifespan of the patients was significantly extended by Bria-IMT™ in some cases by fivefold. The tumor regression occurred rapidly with few side effects. Additionally, tumor regression was observed in other sites including the lung and the brain.
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