CNS Pharmaceuticals is a pre-clinical stage biotechnology company specializing in the development of novel treatments for brain tumors.
Our lead drug, Berubicin, is an exciting discovery for the treatment of Glioblastoma Multiforme (GBM) and potentially for other CNS malignancies. Berubicin was first discovered at the MD Anderson Cancer Center, one of the largest cancer institutes in the world.
CNS has obtained a worldwide exclusive license to the Berubicin patent from Houston Pharmaceuticals, the original commercial holder of the Berubicin intellectual property.
CNS has also acquired all data and know-how related to the Phase 1 trial of Berubicin from Reata Pharmaceuticals, a multibillion dollar NASDAQ listed company. In 2017, CNS entered into a collaboration agreement with Reata to further advance the development of Berubicin.
In 2020, with the funding secured from our NASDAQ IPO, CNS will commence its Phase 2(a) clinical trial of Berubicin for the treatment of GBM.
CNS may also pursue the development of Berubicin to treat additional diseases, including pancreatic and ovarian cancers and lymphoma. CNS may also develop combination therapies that include Berubicin.
Based on human clinical trial data, our lead drug called Berubicin, which was developed at the M.D. Anderson Cancer Center, the largest cancer treatment and research institute in the world, has been shown to get across the blood brain barrier and kill brain tumor cells not reachable by other therapies. In other words, Berubicin may become an effective treatment against glioblastoma, the most aggressive type of brain cancer.
BERUBICIN PHASE I CLINICAL TRIAL
This is a scan of a patient’s glioblastoma in Berubicin’s Phase 1 clinical trial where 44% of the patients showed a clinical response. Berubicin is one of the first anthracycline’s that does not require a specific carrier to be able to cross over the blood brain barrier and get into the brain. None of the drugs that require carriers have been shown to be effective in humans.
What is Glioblastoma?
Glioblastoma is the most aggressive type of brain cancer, where the average survival is only 14 to 16 months after diagnosis – essentially a death sentence for those afflicted with it. Glioblastoma is the type of brain cancer that led to the death of Senator Ted Kennedy, Vice President Joe Biden’s son and most recently, the passing of Senator John McCain. It’s important to understand that there is currently no proven cure for this aggressive disease.
What are Anthracyclines?
Anthracyclines are among the most effective anticancer treatments ever developed, and have played a prominent role in the treatment of more types of cancer than any other class of chemotherapeutic agents. According to academic literature, Anthracyclines have demonstrated anti-tumor activity in a wide range of cancers including breast, stomach, uterine, ovarian, bladder, lung and hematological malignancies.
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