REPROGRAMMING THE COURSE OF CANCER
At Genprex, we are committed to pioneering a new approach to treating cancer, based upon our novel proprietary technology platform, including our initial product candidate, Oncoprex™ immunogene therapy, or Oncoprex. Our platform technologies are designed to administer cancer fighting genes by encapsulating them into nanoscale hollow spheres called nanovesicles, which are then administered intravenously and taken up by tumor cells where they express proteins that are missing or found in low quantities.
Our mission is to develop life-changing gene technologies for cancer patients through unique, innovative science.
Genprex is a clinical stage gene therapy company committed to pioneering a new approach to treating cancer. We are developing potentially life-changing gene technologies based upon our novel proprietary technology platform, including our initial product candidate, Oncoprex™ immunogene therapy, or Oncoprex. Our platform technologies are designed to administer cancer fighting genes by encapsulating them into nanoscale hollow spheres called nanovesicles. The nanovesicles are then administered intravenously and are taken up by tumor cells where they express proteins that are missing or found in low quantities.
Our lead product candidate, Oncoprex™, targets non-small cell lung cancer. This initial cancer target represents about 85 percent of all lung cancers and causes more deaths each year than any other type of cancer. Lung cancer is the second most common form of cancer, and the five-year survival rate for late stage lung cancer has not improved substantially in a quarter century. Research indicates that our platform technologies may deliver a number of other cancer fighting genes, alone or in combination with other cancer therapies, to combat additional types of cancer.
Commitment – We are committed to fighting cancer by continuing to develop unique and innovative gene therapies.
Excellence – Our pioneering technologies are at the forefront of gene therapy and we stand behind our high-quality technology platform.
Integrity – We have integrity and high ethical standards, and we believe in responsibly transforming the lives of those affected with cancer.
Leadership – Our commitment, excellence in technology, and integrity behind what we do enables us to be trailblazers in the effort to change the lives of cancer patients.
OUR TECHNOLOGY
Cancer
Cancer is a complex disease that can start in any site in the body when a tissue grows out of control and inhibits the body’s normal functioning. At the cell level, cancer often involves the dysregulation of multiple genes and cellular pathways, leading to the cell’s inability to maintain proper cellular functions. Re-establishing or blocking these pathways can be done through many therapeutic approaches, including gene therapy. More general information about cancer can be found at The American Cancer Society
Lung Cancer
Genprex’s research and development projects are focused on developing new treatments for cancer. Our initial therapeutic target is non-small cell lung cancer (NSCLC). Lung cancer is one of the most prevalent and deadly cancers worldwide, and NSCLC comprises about 85 percent of lung cancers. The five year survival rate for late stage lung cancer has not improved significantly in the past 25 years despite advances in drug development and novel therapeutic standards. Our objective at Genprex is to develop cutting-edge gene therapies to improve patient outcomes.
The Genprex Approach
We are developing gene therapies for treatment of cancer, including our initial drug candidate Oncoprex immunogene therapy. Our gene therapies are designed to administer cancer fighting genes by encapsulating them into nanoscale hollow spheres called nanovesicles, which are then administered intravenously and taken up by tumor cells where they express proteins that are missing or found in low quantities. Our research indicates that when Oncoprex is combined with targeted therapies (such as Tarceva or Iressa) or immunotherapies (such as Opdivo and Yervoy), Oncoprex is synergistic with those drugs, meaning that the combination is more effective than either drug alone. We believe that by combining Oncoprex with targeted therapies and immunotherapies, we can extend the benefit of these approved lung cancer drugs into the large majority of patients who do not now benefit from them, either because the patients’ tumors do not have the molecular profiles that indicate effectiveness of those drugs, or because the patients have developed resistance to those drugs after receiving them for some period of time.
We hold a portfolio of more than 30 patents covering our technologies and targeted molecular therapies.
We are also conducting pre-clinical research to identify biomarkers that will identify patients most likely to benefit from our gene therapies; and to identify additional cancer drugs that will be synergistic with our gene therapies.
Targeted molecular therapies and immunotherapies offer new options for cancer patients.
As targeted therapies and immunotherapies supplant conventional chemotherapies in lung cancer, many lung cancer patients who do not meet specific genomic profiles are unable to benefit from these new therapies. In fact, a majority of lung cancer patients cannot benefit from targeted therapies or immunotherapies. Genprex seeks to bridge a critical gap by combining its gene therapies with targeted therapies and immunotherapies to provide treatments to large patient populations who would otherwise not be candidates for those important drugs.
In a phase I/II clinical trial, Genprex’s leading drug candidate, Oncoprex, is being combined with the EGFR TKI drug Tarceva® (erlotinib) in Stage IIIb/IV non-small cell lung cancer (NSCLC) patients without an activating EGFR mutation and in patients with an activating EGFR mutation who progressed on erlotinib, whether or not they had prior chemotherapy. Patients without an activating EGFR mutation represent the vast majority of lung cancer patients, however these patients are usually not candidates for EGFR TKI therapies due to the absence of this mutation.
Oncoprex is being developed to overcome this genomic limitation and provide a new treatment solution to this majority of lung cancer patients who do not have the activating EGFR mutation that would allow them to benefit from EGFR TKI therapies such as Tarceva.
In addition, patients who have the EGFR activating mutation and do receive an EGFR TKI inhibitor such as Tarceva usually become resistant to these drugs at some point, and no longer benefit from them. Data indicate that Oncoprex may re-sensititize these patients to EGFR TKI drugs such as Tarceva, allowing the patients to benefit for a longer period time.
Source: https://www.genprex.com/
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